Chronic cystitis with bladder disorders

What is Cystitis?

Cystitis is the medical term for inflammation of the bladder.

In recent years there has been an increasing number of studies advocating a significant role of glycosaminoglycans (GAGs) disorder in the pathogenesis of chronic bladder diseases.3,4


Intact GAG layer

The bladder is protected by a mucous layer known as the GAG layer and is thought to protect the underlying urothelium from irritants contained in urine.3

Damaged GAG layer

There is evidence that the GAG layer of the bladder is deficient in cystitis. This deficiency contributes to the clinical symptoms in the diseases such as interstitial cystitis, cystitis caused by infections, trauma, urolithiasis, urinary retention, neoplasia and radiation induced cystitis.5

2.COB Foundation. Cystitis Handbook: The Cystitis & Overactive Bladder Foundation 2012. 3. Cicione A, Cantiello F, Ucciero G, et al. Intravesical treatment with highly-concentrated hyaluronic acid and chondroitin sulphate in patients with recurrent urinary tract infections: Results from a multicentre survey. Can Urol Assoc J. 2014;8(9-10):E721-7. 4.Fiander N. Painful bladder syndrome and interstitial cystitis: treatment options. Br J Nurs. 2013;22(9):S26, S8-33. 5.Cystistat® patient information leaflet